Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Abstract Background Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymeth...

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Main Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:Clinical Epigenetics
Assuntos:
Alzheimer’s disease (AD)
Brain
Ankyrin 1 (ANK1)
DNA methylation (5mC)
DNA hydroxymethylation (5hmC)
Entorhinal cortex (EC)
Acesso em linha:http://link.springer.com/article/10.1186/s13148-019-0636-y
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