Routes of Clonal Evolution into Complex Karyotypes in Myelodysplastic Syndrome Patients with 5q Deletion

Myelodysplastic syndrome (MDS) can easily transform into acute myeloid leukemia (AML), a process which is often associated with clonal evolution and development of complex karyotypes. Deletion of 5q (del(5q)) is the most frequent aberration in complex karyotypes. This prompted us to analyze clonal e...

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Main Authors: Simone Feurstein, Kathrin Thomay, Winfried Hofmann, Guntram Buesche, Hans Kreipe, Felicitas Thol, Michael Heuser, Arnold Ganser, Brigitte Schlegelberger, Gudrun Göhring
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Assuntos:
myelodysplastic syndrome
clonal evolution
chromothripsis
complex karyotype
TP53
Acceso en liña:http://www.mdpi.com/1422-0067/19/10/3269
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