V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA break and subsequent repair. DNA cleavage is initiated by the recombinase complex, consisting of lymphocyte specific pro...

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Main Authors: Shaun M. Christie, Carel Fijen, Eli Rothenberg
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
V(D)J rearrangements
DNA repair
nonhomologous end joining
chromatin 3D architecture
recombinase activating gene
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2022.886718/full
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