Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens

Abstract Background Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lea...

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Main Authors: Phuong T. Lam, Stephanie L. Padula, Thanh V. Hoang, Justin E. Poth, Lin Liu, Chun Liang, Adam S. LeFever, Lindsay M. Wallace, Ruth Ashery-Padan, Penny K. Riggs, Jordan E. Shields, Ohad Shaham, Sheldon Rowan, Nadean L. Brown, Tom Glaser, Michael L. Robinson
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2019-02-01
Sraith:Human Genomics
Ábhair:
Cre recombinase
Lens development
Transgenic mice
Rochtain Ar Líne:http://link.springer.com/article/10.1186/s40246-019-0192-8
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