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Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate.
The mechanism of membrane fusion by "class II" viral fusion proteins follows a pathway that involves large-scale domain rearrangements of the envelope glycoprotein (E) and a transition from dimers to trimers. The rearrangement is believed to proceed by an outward rotation of the E ectodoma...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2010-04-01
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| Colecção: | PLoS Pathogens |
| Acesso em linha: | http://europepmc.org/articles/PMC2851732?pdf=render |
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