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Intratumor Heterogeneity of K-Ras and p53 Mutations among Human Colorectal Adenomas Containing Early Cancer

The molecular pathways and the timing of genetic events during human colorectal carcinogenesis are still not fully understood. We have addressed the intratumor heterogeneity of the mutational status of the k‐ras oncogene and of the p53 oncosuppressor gene during the adenoma–carcinoma sequence by inv...

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Detalhes bibliográficos
Main Authors: Walter Giaretti, Barbara Macciocu, Elio Geido, Mario Hermsen, Cindy Postma, Jan Baak, Richard Williams, Gerrit Meijer
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2000-01-01
Colecção:Analytical Cellular Pathology
Acesso em linha:http://dx.doi.org/10.1155/2000/747524
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