Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

Abstract Background Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer agents. Previous work revealed that cells from murine osteosarcomas we...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott, Christine J. Hawkins
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-09-01
Serier:BMC Cancer
Fag:
Osteosarcoma
Bone cancer
Sarcoma
Smac mimetic
IAP antagonist
Metastasis
Online adgang:http://link.springer.com/article/10.1186/s12885-019-6103-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker