The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

Host innate immune defences play a critical role in restricting the intracellular propagation and pathogenesis of invading viral pathogens. Here we show that the histone H3.3 chaperone HIRA (histone cell cycle regulator) associates with promyelocytic leukaemia nuclear bodies (PML-NBs) to stimulate t...

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Autors principals: Steven McFarlane, Anne Orr, Ashley P E Roberts, Kristen L Conn, Victor Iliev, Colin Loney, Ana da Silva Filipe, Katherine Smollett, Quan Gu, Neil Robertson, Peter D Adams, Taranjit Singh Rai, Chris Boutell
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2019-03-01
Col·lecció:PLoS Pathogens
Accés en línia:https://doi.org/10.1371/journal.ppat.1007667
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