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The Direct Assignment Option as a Modular Design Component: An Example for the Setting of Two Predefined Subgroups
Background. A phase II design with an option for direct assignment (stop randomization and assign all patients to experimental treatment based on interim analysis, IA) for a predefined subgroup was previously proposed. Here, we illustrate the modularity of the direct assignment option by applying it...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Limited
2015-01-01
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| Colecção: | Computational and Mathematical Methods in Medicine |
| Acesso em linha: | http://dx.doi.org/10.1155/2015/210817 |
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