The roles of individual mammalian argonautes in RNA interference in vivo.

Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3' untranslated region (3'UTR) of an mRNA, is solely dependent on Ago2 in vitro. These studies utilize...

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Hlavní autoři: Vera M Ruda, Rohit Chandwani, Alfica Sehgal, Roman L Bogorad, Akin Akinc, Klaus Charisse, Alexander Tarakhovsky, Tatiana I Novobrantseva, Victor Koteliansky
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC4081796?pdf=render
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