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Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

Pancreatic cancer is one of the most aggressive cancers whose prognosis is worsened by the poor response to the current chemotherapies. In this study, we investigated the cytotoxic effect of Apigenin, against two pancreatic cell lines, namely Panc1 and PaCa44, harboring different p53 mutations. Apig...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Maria Saveria Gilardini Montani, Nives Cecere, Marisa Granato, Maria Anele Romeo, Luca Falcinelli, Umberto Ciciarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2019-05-01
Cyfres:Cancers
Pynciau:
p62
ROS
SOD
Mynediad Ar-lein:https://www.mdpi.com/2072-6694/11/5/703
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!