Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines

The primary function of toll-like receptor 8 (TLR-8) is the detection of viruses and other microbial pathogens. Recent evidence suggests that TLR-8 also senses host microRNAs (miRNAs) and implicate TLR-8 in autoimmune disorders. This study examined the interaction between miR-1294 and TLR-8. We firs...

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Detalhes bibliográficos
Main Authors: Linda Pluta, Babak Yousefi, Blossom Damania, Asma A. Khan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-12-01
Colecção:Frontiers in Immunology
Assuntos:
microRNA
IL-8
cytokines
TLR-8
miR-1294
NF-κb
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.02860/full
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