Progressive GAA.TTC repeat expansion in human cell lines.

Trinucleotide repeat expansion is the genetic basis for a sizeable group of inherited neurological and neuromuscular disorders. Friedreich ataxia (FRDA) is a relentlessly progressive neurodegenerative disorder caused by GAA.TTC repeat expansion in the first intron of the FXN gene. The expanded repea...

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Bibliographic Details
Main Authors: Scott Ditch, Mimi C Sammarco, Ayan Banerjee, Ed Grabczyk
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2760145?pdf=render
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