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Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases

Summary: Diagnosis of neurodegenerative diseases hinges on “seed” proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom. To define preferential protein-protein contacts mediat...

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Main Authors: Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Akshatha Ganne, Samuel Kakraba, Narsimha Reddy Penthala, Xiuxia Du, Peter A. Crooks, Sue T. Griffin, Robert J. Shmookler Reis
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2019-10-01
סדרה:iScience
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2589004219303645
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