Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing systemic and local inflammation. IL-37 protein is expressed in healthy and diseased bowel and liver tissue. Here, we tested whether transgenic expr...

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Main Authors: Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
Colecção:Frontiers in Immunology
Assuntos:
chronic colitis
carcinogenesis
cytokines
inflammation
IL-37
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.02632/full
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