Identification of elongation factor G as the conserved cellular target of argyrin B.

Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria, via resistant mutant selection and whole genome sequencing, biophysical binding studi...

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Main Authors: Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, Christina A Kirby, Lewis Whitehead, Robert Yu, Gejing Deng, Ruth E Caughlan, Angela L Woods, Adriana K Jones, S Whitney Barnes, John R Walker, Swann Gaulis, Ervan Hauy, Saskia M Brachmann, Philipp Krastel, Christian Studer, Ralph Riedl, David Estoppey, Thomas Aust, N Rao Movva, Zuncai Wang, Michael Salcius, Gregory A Michaud, Gregory McAllister, Leon O Murphy, John A Tallarico, Christopher J Wilson, Charles R Dean
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3438169?pdf=render
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