IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

Abstract Background Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary depending on the levels and the types of inflammatory cytokines. However, how...

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Autori principali: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi, Changshun Shao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-01-01
Serie:Stem Cell Research & Therapy
Soggetti:
Mesenchymal stem/stromal cells
Inflammation
iNOS
Nitric oxide
Autophagy
Apoptosis
Accesso online:http://link.springer.com/article/10.1186/s13287-018-1102-z
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