Tryptophan-Containing Dual Neuroprotective Peptides: Prolyl Endopeptidase Inhibition and Caenorhabditis elegans Protection from β-Amyloid Peptide Toxicity

Neuroprotective peptides represent an attractive pharmacological strategy for the prevention or treatment of age-related diseases, for which there are currently few effective therapies. Lactoferrin (LF)-derived peptides (PKHs) and a set of six rationally-designed tryptophan (W)-containing heptapepti...

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Detalhes bibliográficos
Main Authors: Paloma Manzanares, Roberto Martínez, Sandra Garrigues, Salvador Genovés, Daniel Ramón, Jose F. Marcos, Patricia Martorell
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
neurodegenerative diseases
amyloid β peptide
Caenorhabditis elegans
prolyl endopeptidase inhibition
lactoferrin-derived peptides
rationally-designed peptides
tryptophan
molecular docking
Acesso em linha:http://www.mdpi.com/1422-0067/19/5/1491
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