Prokaryotic soluble overexpression and purification of bioactive human growth hormone by fusion to thioredoxin, maltose binding protein, and protein disulfide isomerase.

Human growth hormone (hGH) is synthesized by somatotroph cells of the anterior pituitary gland and induces cell proliferation and growth. This protein has been approved for the treatment of various conditions, including hGH deficiency, chronic renal failure, and Turner syndrome. Efficient production...

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Auteurs principaux: Minh Tan Nguyen, Bon-Kyung Koo, Thu Trang Thi Vu, Jung-A Song, Seon-Ha Chong, Boram Jeong, Han-Bong Ryu, Sang-Hyun Moh, Han Choe
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2014-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC3948679?pdf=render
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