Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands

In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlorophenyl)-<i>N</i>-piperidin-1-yl-4,5-dihydrobenzo-1<i>H</i>-6-oxa-cyclohepta[1,2-<i>c</i>]pyrazole-3-carboxamide <b>1a</b> and its deaza <i>N-<...

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Bibliografski detalji
Glavni autori: Gabriele Murineddu, Battistina Asproni, Paola Corona, Sandra Piras, Paolo Lazzari, Stefania Ruiu, Laura Legnani, Lucio Toma, Gérard A. Pinna
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2019-04-01
Serija:Molecules
Teme:
cannabinoid receptor 1 neutral antagonists
synthesis
structure-activity relationship studies
food intake
gastrointestinal transit
modelling studies
Online pristup:https://www.mdpi.com/1420-3049/24/9/1656
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