Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration

The nonreducing disaccharide trehalose has been long considered only as a reserve carbohydrate. However, recent studies in yeast suggested that this osmolyte can protect cells and cellular proteins from oxidative damage elicited by exogenously added reactive oxygen species (ROS). Trehalose has been...

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Detalhes bibliográficos
Main Authors: Pavlo eKyryakov, Adam eBeach, Vincent R. Richard, Michelle T. Burstein, Anna eLeonov, Sean eLevy, Vladimir eTitorenko
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012-07-01
Colecção:Frontiers in Physiology
Assuntos:
Caloric Restriction
Longevity
Trehalose
yeast
proteostasis
cellular aging
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00256/full
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