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Blocking TGF-β Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils
In the tumor microenvironment (TME), cells secrete a cytokine known as transforming growth factor-β (TGF-β), which polarizes tumor-associated neutrophils (TANs) towards a protumor phenotype. In this work, C57BL/6 mice with TGF-β1 gene knocked out selectively in myofibroblasts receive orthotopic impl...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Limited
2022-01-01
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| Colecção: | Journal of Oncology |
| Acesso em linha: | http://dx.doi.org/10.1155/2022/3447185 |
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