Hemodynamic Effects of Alpha-Tropomyosin Mutations Associated with Inherited Cardiomyopathies: Multiscale Simulation

The effects of two cardiomyopathy-associated mutations in regulatory sarcomere protein tropomyosin (Tpm) on heart function were studied with a new multiscale model of the cardiovascular system (CVS). They were a Tpm mutation, Ile284Val, associated with hypertrophic cardiomyopathy (HCM), and an Asp23...

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Main Authors: Fyodor Syomin, Albina Khabibullina, Anna Osepyan, Andrey Tsaturyan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Mathematics
Assuntos:
mathematical modeling
cardiac mechanics
multiscale simulation
cardiomyopathies
left ventricle remodeling
Acesso em linha:https://www.mdpi.com/2227-7390/8/7/1169
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