Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.

Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated with the aggressiveness of the disease. The steroid...

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Main Authors: Jack U Flanagan, Yuliana Yosaatmadja, Rebecca M Teague, Matilda Z L Chai, Andrew P Turnbull, Christopher J Squire
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2012-01-01
סדרה:PLoS ONE
גישה מקוונת:http://europepmc.org/articles/PMC3429426?pdf=render
תגים: הוספת תג
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