Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.

Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated with the aggressiveness of the disease. The steroid...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jack U Flanagan, Yuliana Yosaatmadja, Rebecca M Teague, Matilda Z L Chai, Andrew P Turnbull, Christopher J Squire
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science (PLoS) 2012-01-01
Cyfres:PLoS ONE
Mynediad Ar-lein:http://europepmc.org/articles/PMC3429426?pdf=render
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