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Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease.

Caffeine has been considered a neuroprotective agent against Parkinson's disease (PD). Recent metabolomic analysis showed that levels of caffeine and its metabolites were decreased in sera from patients with PD compared with those from healthy controls. We focused on theophylline, which is one...

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Main Authors: Takuma Ohmichi, Takashi Kasai, Tadashi Kosaka, Keisuke Shikata, Harutsugu Tatebe, Ryotaro Ishii, Makiko Shinomoto, Toshiki Mizuno, Takahiko Tokuda
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC6059449?pdf=render
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