Morphine-3-Glucuronide, Physiology and Behavior

Morphine remains the gold standard painkiller available to date to relieve severe pain. Morphine metabolism leads to the production of two predominant metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). This metabolism involves uridine 5′-diphospho-glucuronosyltransferases (U...

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Bibliographic Details
Main Authors: Florian Gabel, Volodya Hovhannisyan, Abdel-Karim Berkati, Yannick Goumon
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
morphine
metabolism
M3G
hyperalgesia
MOR – mu opioid receptor
TLR4 – toll-like receptor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.882443/full
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