Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we constructe...

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Main Authors: Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. James Shen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:Acta Neuropathologica Communications
Assuntos:
Circular RNAs/ frontotemporal lobar degeneration/ loss-of-function/ Mis-processing/TDP-43
Acesso em linha:http://link.springer.com/article/10.1186/s40478-019-0674-x
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