TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration

Transactive response DNA-binding protein of ∼43 kDa (TDP-43), a primary pathologic substrate in tau-negative frontotemporal lobar degeneration (FTLD), is also often found in the brains of elderly individuals without FTLD and is a key player in the process of neurodegeneration in brains with and with...

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Autori principali: Marina Buciuc, Peter R. Martin, Nirubol Tosakulwong, Melissa E. Murray, Leonard Petrucelli, Matthew L. Senjem, Anthony J. Spychalla, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Dennis W. Dickson, Clifford R. Jack, Jr., Jennifer L. Whitwell, Keith A. Josephs
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2022-01-01
Serie:NeuroImage: Clinical
Soggetti:
Alzheimer’s disease
TDP-43
MRI
LATE
Old age FTLD
Accesso online:http://www.sciencedirect.com/science/article/pii/S2213158222000195
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