Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia

ABSTRACT The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there is an urgent need to identify novel anti-infective agents to attack new targets to overcome antibiotic resis...

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Main Authors: Shisong Jing, Xiangri Kong, Li Wang, Heming Wang, Jiaxuan Feng, Lin Wei, Ying Meng, Chang Liu, Xiren Chang, Yishen Qu, Jiyu Guan, Haimiao Yang, Chi Zhang, Yicheng Zhao, Wu Song
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-04-01
Serier:Microbiology Spectrum
Fag:
MRSA
antivirulence
inhibitor
caseinolytic peptidase P
pneumonia
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.02340-21
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