Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer

Controversy persists regarding metformin’s role in cancer therapy. Our recent work suggested metformin acts by impacting the tumor microenvironment (TME), normalizing the epigenetic profile of cancer-associated mesenchymal stem cells (CA-MSC). As CA-MSC can negatively impact tumor immune infiltrates...

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Hlavní autoři: Sarah E. Taylor, Daniel K. Chan, Dongli Yang, Tulia Bruno, Richard Lieberman, Javed Siddiqui, Thing Rinda Soong, Lan Coffman, Ronald J. Buckanovich
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2022-05-01
Edice:Cancers
Témata:
epithelial ovarian cancer
tumor microenvironment
cancer-associated mesenchymal stem cells
metformin
On-line přístup:https://www.mdpi.com/2072-6694/14/9/2298
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