Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer

Controversy persists regarding metformin’s role in cancer therapy. Our recent work suggested metformin acts by impacting the tumor microenvironment (TME), normalizing the epigenetic profile of cancer-associated mesenchymal stem cells (CA-MSC). As CA-MSC can negatively impact tumor immune infiltrates...

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Detalhes bibliográficos
Main Authors: Sarah E. Taylor, Daniel K. Chan, Dongli Yang, Tulia Bruno, Richard Lieberman, Javed Siddiqui, Thing Rinda Soong, Lan Coffman, Ronald J. Buckanovich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
Colecção:Cancers
Assuntos:
epithelial ovarian cancer
tumor microenvironment
cancer-associated mesenchymal stem cells
metformin
Acesso em linha:https://www.mdpi.com/2072-6694/14/9/2298
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