Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer

Controversy persists regarding metformin’s role in cancer therapy. Our recent work suggested metformin acts by impacting the tumor microenvironment (TME), normalizing the epigenetic profile of cancer-associated mesenchymal stem cells (CA-MSC). As CA-MSC can negatively impact tumor immune infiltrates...

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Главные авторы: Sarah E. Taylor, Daniel K. Chan, Dongli Yang, Tulia Bruno, Richard Lieberman, Javed Siddiqui, Thing Rinda Soong, Lan Coffman, Ronald J. Buckanovich
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2022-05-01
Серии:Cancers
Предметы:
epithelial ovarian cancer
tumor microenvironment
cancer-associated mesenchymal stem cells
metformin
Online-ссылка:https://www.mdpi.com/2072-6694/14/9/2298
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