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Method for Therapeutic Drug Monitoring of Voriconazole and its Primary Metabolite Voriconazole-N-oxide in Human Serum using LC-MS/MS

OBJECTIVES: his study aims to present a strategy to optimize a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for voriconazole and voriconazole-N-oxide with an stable isotopically labelled internal standard. METHODS: Protein precipitation was used as extraction method...

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Detalhes bibliográficos
Main Authors: Mendy ter Avest, Anette Veringa, Kai van Hateren, Remco A. Koster, Daan J. Touw, Jan-Willem C. Alffenaar
Formato: Artigo
Idioma:Inglês
Publicado em: Betasciencepress Publishers 2018-10-01
Colecção:Journal of Applied Bioanalysis
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Acesso em linha:https://doi.org/10.17145/jab.18.016
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