Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS

The purpose of this study was to identify potential metabolic pathways and metabolites of OJT007, a methionine aminopeptidase 1 (MetAP1) inhibitor. OJT007 is a novel drug with potent antiproliferative effects against Leishmania Major. We conducted in vitro Phase I oxidation and Phase II glucuronidat...

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Main Authors: Maria Eugenia Rincon Nigro, Ting Du, Song Gao, Manvir Kaur, Huan Xie, Omonike Arike Olaleye, Dong Liang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Molecules
Assuntos:
LC-MS/MS
liver microsomes
metabolic stability
UGT
CYP450
Acesso em linha:https://www.mdpi.com/1420-3049/27/9/2854
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