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Microtubule Actin Cross-linking Factor 1 regulates cardiomyocyte microtubule distribution and adaptation to hemodynamic overload.

Aberrant cardiomyocyte microtubule growth is a feature of pressure overload induced cardiac hypertrophy believed to contribute to left ventricular (LV) dysfunction. Microtubule Actin Cross-linking Factor 1 (MACF1/Acf7) is a 600 kd spectraplakin that stabilizes and guides microtubule growth along act...

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Autors principals: John T Fassett, Xin Xu, Dongmin Kwak, Huan Wang, Xiaoyu Liu, Xinli Hu, Robert J Bache, Yingjie Chen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2013-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC3784444?pdf=render
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