Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Abstract Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study directly assessed the clinical translatability of the...

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Huvudupphovsmän: Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2020-07-01
Serie:BMC Gastroenterology
Ämnen:
Non-alcoholic steatohepatitis
Mouse model
Diet-induced obesity
Translatability
Histopathology
Histomorphometry
Länkar:http://link.springer.com/article/10.1186/s12876-020-01356-2
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