Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Abstract Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study directly assessed the clinical translatability of the...

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Main Authors: Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
Colecção:BMC Gastroenterology
Assuntos:
Non-alcoholic steatohepatitis
Mouse model
Diet-induced obesity
Translatability
Histopathology
Histomorphometry
Acesso em linha:http://link.springer.com/article/10.1186/s12876-020-01356-2
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