TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4<sup>+</sup> T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation o...

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Autori principali: Mellanby Richard J, Cambrook Helen, Turner Darryl G, O’Connor Richard A, Leech Melanie D, Kurschus Florian C, MacDonald Andrew S, Arnold Bernd, Anderton Stephen M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2012-10-01
Serie:Journal of Neuroinflammation
Soggetti:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Dendritic cells
Myelin basic protein
Accesso online:http://www.jneuroinflammation.com/content/9/1/248
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