Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein

Although well characterized as a transcriptional activator that drives prostate cancer (PCa) growth, androgen receptor (AR) can function as a transcriptional repressor, and high-level androgens can suppress PCa proliferation. The molecular basis for this repression activity remains to be determined....

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Autori principali: Shuai Gao, Yanfei Gao, Housheng Hansen He, Dong Han, Wanting Han, Amy Avery, Jill A. Macoska, Xiaming Liu, Sen Chen, Fen Ma, Shaoyong Chen, Steven P. Balk, Changmeng Cai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016-10-01
Serie:Cell Reports
Soggetti:
prostate cancer
androgen receptor
AR
androgen deprivation therapy
transcriptional repression
DNA replication
DNA damage repair
metabolism
Retinoblastoma protein
Rb
E2F1
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124716313201
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