TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells

The aberrant activation of the ERG oncogenic pathway due to the TMPRSS2-ERG gene fusion is the major event that contributes to prostate cancer (PCa) development. However, the critical downstream effectors that can be therapeutically targeted remain to be identified. In this study, we have found that...

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Udgivet i:Oncogene
Main Authors: Zhou, Feng, Gao, Shuai, Han, Dong, Han, Wanting, Chen, Sujun, Patalano, Susan, Macoska, Jill A., He, Housheng Hansen, Cai, Changmeng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542710/
https://ncbi.nlm.nih.gov/pubmed/30718921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0730-9
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