iRegulon: from a gene list to a gene regulatory network using large motif and track collections.

Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regula...

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Auteurs principaux: Rekin's Janky, Annelien Verfaillie, Hana Imrichová, Bram Van de Sande, Laura Standaert, Valerie Christiaens, Gert Hulselmans, Koen Herten, Marina Naval Sanchez, Delphine Potier, Dmitry Svetlichnyy, Zeynep Kalender Atak, Mark Fiers, Jean-Christophe Marine, Stein Aerts
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2014-07-01
Collection:PLoS Computational Biology
Accès en ligne:http://europepmc.org/articles/PMC4109854?pdf=render
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