Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis

Background/Aims: The Cl-/HCO3- exchanger pendrin and the thiazide-sensitive Na-Cl cotransporter NCC are expressed in the kidney distal nephron and mediate salt absorption. We hypothesized that deletion of pendrin leaves NCC as the major salt absorbing transporter in the distal nephron and therefore...

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Main Authors: Saeed Alshahrani, Manoocher Soleimani
Formato: Artigo
Idioma:Inglês
Publicado: Karger Publishers 2017-07-01
Series:Kidney & Blood Pressure Research
Assuntos:
Hypertension
Kidney
Pendrin
NCC
Thiazides
Acceso en liña:http://www.karger.com/Article/FullText/479296
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