Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action

Insulin analogs were developed to improve diabetes therapy. However, certain modifications introduced into the insulin molecule were shown to enhance their affinity to the insulin-like growth factor-1 receptor (IGF1R). Most tumors, including endometrial cancers, express high levels of IGF1R. The pre...

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Hlavní autoři: Daniel Aizen, Metsada Pasmanik-Chor, Rive Sarfstein, Zvi Laron, Ilan Bruchim, Haim Werner
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-03-01
Edice:Frontiers in Endocrinology
Témata:
insulin-like growth factor-1
insulin analogues
endometrial cancer
microarray analysis
filamin-A
On-line přístup:http://journal.frontiersin.org/article/10.3389/fendo.2018.00105/full
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