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Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action

Insulin analogs were developed to improve diabetes therapy. However, certain modifications introduced into the insulin molecule were shown to enhance their affinity to the insulin-like growth factor-1 receptor (IGF1R). Most tumors, including endometrial cancers, express high levels of IGF1R. The pre...

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Main Authors: Daniel Aizen, Metsada Pasmanik-Chor, Rive Sarfstein, Zvi Laron, Ilan Bruchim, Haim Werner
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018-03-01
Sraith:Frontiers in Endocrinology
Ábhair:
Rochtain Ar Líne:http://journal.frontiersin.org/article/10.3389/fendo.2018.00105/full
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