The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in...

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Autores principales: Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018-07-01
Colección:Frontiers in Cellular Neuroscience
Materias:
acetyl-CoA
acetylcholine
N-acetyl-L-aspartate
nerve growth factor
protein acetylations
metabolic compartmentation
Acceso en línea:https://www.frontiersin.org/article/10.3389/fncel.2018.00169/full
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