Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs

The chemical structure of a drug determines its physicochemical properties, further determines its ADME/Tox properties, and ultimately affects its pharmacological activity. Medicinal chemists can regulate the pharmacological activity of drug molecules by modifying their structure. Ring systems and f...

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Библиографические подробности
Главные авторы: Fei Mao, Wei Ni, Xiang Xu, Hui Wang, Jing Wang, Min Ji, Jian Li
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2016-01-01
Серии:Molecules
Предметы:
drug-like property
chemical structure-related criteria
ring system
functional group
the heavy atoms proportion
drug design
Online-ссылка:http://www.mdpi.com/1420-3049/21/1/75
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