Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese <it>db/db</it> mice

<p>Abstract</p> <p>Background</p> <p>Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a parti...

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Autori principali: Shiota Asuka, Shimabukuro Michio, Fukuda Daiju, Soeki Takeshi, Sato Hiromi, Uematsu Etsuko, Hirata Yoichiro, Kurobe Hirotsugu, Maeda Norikazu, Sakaue Hiroshi, Masuzaki Hiroaki, Shimomura Iichiro, Sata Masataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2012-11-01
Serie:Cardiovascular Diabetology
Soggetti:
Adiponectin
AMP-activated protein kinase
Obesity
Peroxisome proliferator-activated receptor-γ
SIRT1
Accesso online:http://www.cardiab.com/content/11/1/139
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