Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and pro-inflammatory mediators. In Crohn’s disease (CD), TACE activity is upregulated, resulting in a marked increase of TNFα secretion and inflammation. Altho...

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Main Authors: Taylor J. Louis, Ahmad Qasem, Saleh A. Naser
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
TACE (TNF-α converting enzyme)
rhomboid proteins
mycobacteria paratuberculosis
Crohn's disease
ectodomain shedding
iRHOM 1/2
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887830/full
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