A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril

Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide. Upon oral administration racecadotril is rapidly and effectively converted into the act...

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Main Authors: Marion eEberlin, Thomas eMück, Martin C Michel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012-05-01
Serier:Frontiers in Pharmacology
Fag:
Analgesia
Diarrhea
Hypertension
Loperamide
racecadotril
neutral endopeptidase
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00093/full
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